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Updated: Jul 28, 2026
Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling
Published on: May 30, 2011
Dynamic observation of pulmonary perfusion using continuous arterial spin-labeling in a pig model
D A Roberts1, R R Rizi, D A Lipson
1Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283, USA. roberts@oasis.rad.upenn.edu
Abstract:
The continuous arterial spin-labeling (CASL) method of perfusion MRI is used to observe pulmonary perfusion dynamically in an animal model. Specifically, a respiratory-triggered implementation of the CASL method is used with approximate spatial resolution of 0.9 x 1.8 x 5.0 mm (0.008 cc) and 2-minute temporal resolution. Perfusion MRI is performed dynamically during repeated balloon occlusion of a segmental pulmonary artery, as well as during pharmacological stimulation. A total of three Yorkshire pigs were studied. The results demonstrate the ability of the endogenous spin-labeling method to characterize the dynamic changes in pulmonary perfusion that occur during important physiological alterations.
