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Updated: Oct 5, 2026

Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
[Blocking action of tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor
1Burn Center, First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006.
Objective:
To investigate the effect of Tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta (TGF-beta).
Methods:
The scar-derived fibroblasts were suspended in a solution of collagen matrix, and TGF-beta, they were associated to form a scar model in vitro. The influence of tetrandrine on the contraction indexes was observed.
Results:
Tetrandrine plays a blocking action in the scar-collagen matrix contraction stimulated by TGF-beta, which was in a dose-dependent manner.
Conclusion:
This function of tetrandrine could be responsible for the anti-scar mechanism.
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