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Updated: Oct 5, 2026

Increasing Pulmonary Artery Pulsatile Flow Improves Hypoxic Pulmonary Hypertension in Piglets
Published on: May 11, 2015
[Change of hymodynamics and circulating endothelial cells in chronic obstructive pulmonary diseases (COPD) and cor
1General Hospital Commission of Science Technology and Industry of National Defence, Beijing 100101.
Objective:
To investigate the vascular endothelial injuries by observing the changes of circulating endothelial cells (CEC) numbers in blood and hemodynamics in COPD and cor pulmonale patients.
Method:
The arterial catheterion technique and CEC collection technique were used, superoxide dismutase (SOD) and malondialdyhyde(MDA) levels were determined respectively.
Result:
mPAP (3.76 +/- 0.75 kPa) and CEC (16.70 +/- 2.65/0.9 microliter), MDA (6.98 +/- 1.47 mumol/L) in the chronic cor pulmonale are higher than that of mPAP (2.09 +/- 0.41 kPa) and CEC (8.48 +/- 2.23 microliters) in COPD, the numbers of CEC are adversely correlated to PaO2 (gamma = 0.9423, P < 0.001) and positively correlated with mPAP (gamma = 0.8270, P < 0.001), superoxide dismutase(SOD) was decreased.
Conclusion:
mPAP, CEC are higher in cor pulmonale than that in COPD, CEC numbers rise when the PaO2 was lowered, hypoxia may worsen the vascular endothelial injuries.
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