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[Clinical study on Zishen Decoction in chronic uric acid nephrosis]
Objective:
To observe the ameliorative effect of Zishen Decoction (ZSD) on chronic uric acid nephrosis (CUAN).
Methods:
The 72 CUAN patients were divided into 2 groups: The group with ZSD treatment, the dose of which was 400 ml/d and group with zyloric as the control, the dose of which was 200 mg/d. The treatment lasted for 8 weeks.
Results:
The general effective rate of the ZSD group was 92.86%; and that of the control group Was 66.67%. There was significant difference between the two groups (P < 0.01). ZSD treatment reduced the levels of blood uric acid, serum creatinine and blood urea nitrogen and the levels of albumin, beta 2-microglobulin and the activity of N-acetyl-D-glucosaminidase in CUAN (P < 0.01). The levels of triglyceride and total cholesterol decreased and the levels of high density lipoprotein cholesterol increased in the serum of ZSD treated CUAN (P < 0.01).
Conclusions:
ZSD exerted obviously ameliorative effect on renal function in CUAN.