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Related Experiment Videos

Lymphocytic and granulocytic hypophysitis: a single centre experience.

N Buxton1, I Robertson

  • 1Department of Neurosurgery, University Hospital, Nottingham NG7 2UH, UK. neilbuxton@doctors.org.uk

British Journal of Neurosurgery
|August 2, 2001
PubMed
Summary

Lymphocytic and granulocytic hypophysitis are rare pituitary masses. Surgical treatment is recommended for diagnosis, with expected good visual outcomes but permanent pituitary function loss.

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Area of Science:

  • Endocrinology
  • Neurosurgery
  • Pathology

Background:

  • Lymphocytic hypophysitis and granulocytic hypophysitis are rare inflammatory conditions affecting the pituitary gland.
  • These conditions present as pituitary masses, often mimicking other sellar lesions.

Observation:

  • A retrospective analysis identified five cases of hypophysitis treated at a single center, accounting for 0.8% of all pituitary mass lesions.
  • The five patients were female, with one pregnant. Presenting symptoms included panhypopituitarism (three patients) and visual disturbances (two patients).

Findings:

  • All patients underwent surgical intervention for diagnosis and treatment.
  • Postoperatively, visual function improved in all cases. However, all patients experienced permanent panhypopituitarism, necessitating long-term hormone replacement therapy.

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  • Mean follow-up was 4 years and 1 month.

    • Implications:

    • Surgical management is crucial for diagnosing hypophysitis.
    • While surgery can restore visual function, permanent pituitary hormone deficiency is a common outcome.
    • Corticosteroids may be used for residual tumor treatment.