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Related Experiment Videos

Ocular penetration of topically applied gentamicin.

B Ellerhost, B Golden, N Jarudi

    Archives of Ophthalmology (Chicago, Ill. : 1960)
    |May 1, 1975
    PubMed
    Summary

    Topical gentamicin sulfate reaches most ocular tissues, except the lens nucleus. Antibiotic levels depend on inflammation, application frequency, and vehicle properties, influencing gentamicin

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    Area of Science:

    • Ophthalmology
    • Pharmacology
    • Microbiology

    Background:

    • Gentamicin sulfate is a widely used antibiotic for ocular infections.
    • Understanding its penetration and persistence in ocular tissues is crucial for effective treatment.

    Purpose of the Study:

    • To quantify the biologically available concentration of gentamicin sulfate in various ocular tissues.
    • To investigate factors influencing gentamicin sulfate levels in ocular tissues.

    Main Methods:

    • A modified disc diffusion bioassay was employed.
    • Measurements were taken in eight ocular tissues from rabbits and humans.

    Main Results:

    • Gentamicin sulfate was detected in all tested ocular tissues except the lens nucleus.
    • Antibiotic activity decayed faster in some tissues (e.g., aqueous humor).
    • Altered corneas (sutured) showed higher antibiotic levels than virgin tissue.
    • Inflammation, application frequency, and interval between drops correlated with tissue antibiotic levels.
    • The vehicle of commercial gentamicin drops exhibited antibacterial potential.

    Conclusions:

    • Topical gentamicin sulfate effectively penetrates most ocular tissues.
    • Tissue-specific factors and application parameters significantly influence gentamicin sulfate bioavailability.
    • The non-antibiotic components of gentamicin formulations may contribute to antibacterial effects.

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