Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hairlessness in Mus musculus. A pathologic study.

R H Rigdon

    Archives of Pathology
    |June 1, 1975
    PubMed
    Summary

    Homozygous albino hairless mice initially develop normal hair, but it progressively disappears by 30-40 days due to hair follicle atrophy. This hair loss affects the entire body except vibrissae.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Consideration of the mechanism of the anemia produced by chloramphenicol in the duck.

    Antibiotics & chemotherapy (Northfield, Ill.)·2014
    Same author

    Blindness in ducks accompanying hypoglycemia.

    The American journal of pathology·2010
    Same author

    A study of oxygen transport in the blood of young and adult domestic ducks.

    The American journal of physiology·2010
    Same author

    Multiple argentaffin tumors (carcinoids) of the rectum.

    American journal of surgery·2010
    Same author

    A consideration of anoxia in the mechanism of death in acute malarial infections.

    Experimental medicine and surgery·2010
    Same author

    A physiologic study of hematopoiesis in the duck with malaria.

    American journal of clinical pathology·2010

    Area of Science:

    • Dermatology
    • Genetics
    • Developmental Biology

    Background:

    • The homozygous albino hairless mouse model exhibits unique hair development characteristics.
    • Early hair growth in these mice mimics that of normal mice.

    Purpose of the Study:

    • To investigate the morphological changes in hair follicles and hair growth in homozygous albino hairless mice.
    • To understand the basis of progressive hair loss in this animal model.

    Main Methods:

    • Macroscopic observation of hair growth and loss patterns.
    • Histological examination of hair bulbs and follicles at different developmental stages.
    • Comparative analysis between hairless mice and normal mice.

    Main Results:

    • Mice display normal hair development initially, with noticeable hair loss beginning around days 6-8.
    • Macroscopic absence of hair occurs by days 30-40, excluding vibrissae.
    • Histological analysis reveals progressive atrophy of hair bulbs and follicles, with rare exceptions in adult mice.

    Conclusions:

    • Progressive hair loss in homozygous albino hairless mice is attributed to the atrophy of hair follicles.
    • The hairless phenotype is a result of degenerative changes in the hair follicle structure after the initial pelage.

    Related Experiment Videos