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A High Throughput MHC II Binding Assay for Quantitative Analysis of Peptide Epitopes
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Peptide loading of nascent MHC class I molecules

S Vukmanović1, M Lilić, F R Santori

  • 1Department of Pathology, and Kaplan Coprehensive Cancer Center, NYU School of Medicine, NY 10016, USA. vukmas01@med.nyu.edu

Archivum Immunologiae Et Therapiae Experimentalis
|August 2, 2001
PubMed

A critical molecular interaction during assembly of the major histocompatibility complex (MHC) class I molecules takes place between the heavy chain and the transporter-associated with antigen-processing (TAP) complex. The recent mapping of regions of the heavy chain involved in the binding to TAP suggests a complex molecular interaction essential for the cell surface expression of the MHC class I. The advances made in understanding the TAP-MHC class I interaction are reviewed and discussed here.

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