Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Iron: deficiencies and requirements.

H Tapiero1, L Gaté, K D Tew

  • 1Laboratoire de Pharmacologie Cellulaire & Moléculaire, Université de Paris Sud, Faculté de Pharmacie, Chatenay Malabry, France. haim.tapiero@cep.u-psud.fr

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|August 2, 2001
PubMed
Summary

Iron deficiency anemia affects millions of children and pregnant women globally. Understanding iron absorption, transport, and regulation is key to developing effective interventions like weekly iron supplementation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Flame retardant tricresyl phosphate gestational exposure induced endocrine and metabolic disruptions in rat.

Toxicology and applied pharmacology·2025
Same author

Cytotoxic and genotoxic evaluation of different synthetic amorphous silica nanomaterials in the V79 cell line.

Toxicology and industrial health·2015
Same author

Cytotoxicity and genotoxicity of panel of single- and multiwalled carbon nanotubes: in vitro effects on normal Syrian hamster embryo and immortalized v79 hamster lung cells.

Journal of toxicology·2014
Same author

Reaction kinetics and targeting to cellular glutathione S-transferase of the glutathione peroxidase mimetic PhSeZnCl and its D,L-polylactide microparticle formulation.

Free radical biology & medicine·2014
Same author

Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome.

Free radical biology & medicine·2014
Same author

Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation.

Free radical biology & medicine·2012

Area of Science:

  • Nutritional Science
  • Biochemistry
  • Human Physiology

Background:

  • Iron deficiency anemia is a significant global health issue, affecting 46% of children and 48% of pregnant women worldwide.
  • The majority of anemia cases are attributed to insufficient iron levels.
  • Iron is essential for numerous physiological processes, but its toxicity necessitates strict regulatory mechanisms.

Purpose of the Study:

  • To review current data on iron regulatory mechanisms, dietary iron sources, and physiological iron requirements.
  • To highlight key molecular players in iron homeostasis, such as the transferrin-transferrin receptor system and iron regulatory proteins (IRPs).
  • To discuss the potential of alternative iron supplementation strategies for managing iron deficiency.

Main Methods:

Related Experiment Videos

  • Review of existing human and animal studies on iron absorption and regulation.
  • Analysis of data on iron transport systems, including transferrin and its receptor.
  • Examination of the role of iron regulatory proteins (IRPs) and iron-responsive elements (IREs) in cellular iron management.

    • Main Results:

    • Amino acids and peptides have been shown to influence intestinal iron absorption.
    • The transferrin-transferrin receptor system is crucial for nonheme iron transport and uptake between organs.
    • Iron regulatory proteins (IRPs) and iron-responsive elements (IREs) provide a molecular basis for maintaining iron homeostasis and preventing toxicity.

    Conclusions:

    • Iron requirements are significantly elevated during pregnancy, necessitating careful management.
    • Weekly iron supplementation is being investigated as a potentially effective public health strategy to combat iron deficiency, particularly in vulnerable populations.
    • Further research into iron metabolism and supplementation is vital for addressing the global burden of iron deficiency anemia.