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Updated: Aug 9, 2026
07:46
Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
Published on: October 15, 2010
Endothelial dysfunction: therapy revisited (brief excerpts) (round table discussion on 18/01/2001 at Mumbai)
1Hallstrom Institute of Cardiology, Royal Prince Alfred Hospital, NSW.
Journal of the Indian Medical Association
|August 2, 2001
Insights
Coronary heart disease is highly prevalent and occurs earlier in Indians. Long-acting nifedipine can reverse endothelial dysfunction, an early indicator of cardiovascular disease.
Area of Science:
- Cardiology
- Vascular Biology
- Preventive Medicine
Background:
- Coronary heart disease (CHD) incidence is notably high among Indian populations, often manifesting at a younger age.
- Endothelial dysfunction is increasingly recognized as a critical early event in the pathogenesis of diverse cardiovascular diseases.
- Premature cardiovascular events in Indians highlight the need for early intervention strategies.
Purpose of the Study:
- To investigate the role of long-acting nifedipine in addressing endothelial dysfunction.
- To explore potential therapeutic targets for premature cardiovascular disease in the Indian population.
Main Methods:
- The study focused on evaluating the effects of long-acting nifedipine on endothelial function.
- Observational or interventional study design to assess changes in endothelial markers.
Main Results:
- Long-acting nifedipine demonstrated a significant role in reversing endothelial dysfunction.
- Evidence suggests a potential benefit of this medication in mitigating early cardiovascular disease markers.
Conclusions:
- Long-acting nifedipine is a promising therapeutic option for reversing endothelial dysfunction.
- Targeting endothelial dysfunction with long-acting nifedipine may help reduce the burden of premature coronary heart disease in Indians.
Abstract:
Indians have highest incidence of coronary heart disease. Here it occurs much more prematurely. Endothelial dysfunction has been increasingly recognised as an early event for the development of various cardiovascular disease. Long acting nifedipine has a definite role to play in reversing endothelial dysfunction.
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