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Updated: Aug 2, 2026

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
Published on: December 1, 2015
Cholesterol effects on the phospholipid condensation and packing in the bilayer: a molecular simulation study
T Róg1, M Pasenkiewicz-Gierula
1Department of Biophysics, Institute of Molecular Biology, Jagiellonian University, Al. Mickiewicza 3, 31-120 Cracow, Poland. tomekr@mol.uj.edu.pl
Abstract:
A 15-ns molecular dynamics simulation of the fully hydrated liquid-crystalline dimyristoylphosphatidylcholine-cholesterol (DMPC-Chol) bilayer containing approximately 22 mol% Chol was carried out. The generated trajectory was analysed to investigate the mechanism of the Chol condensing effect on DMPC hydrocarbon chains and the influence of Chol on the chain packing in the membrane. Chol was found to induce stronger van der Waals interactions among the chains, whereas its interactions with the chains were weak. In the DMPC-Chol bilayer, as in the DMPC bilayer, DMPC chains were regularly packed around a chosen chain but around a Chol molecule they were not. DMPC gamma chains made closer contacts with Chol than the beta chains.
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