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Reactive species in viral pneumonitis: lessons from animal models
1Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35233-6810, USA.
Abstract:
Recent evidence suggests that pneumonitis induced by many important human viral pathogens may result from exuberant generation of reactive species by inflammatory cells in response to infection. This review summarizes current evidence from animal model studies regarding the beneficial (antiviral) and harmful (tissue-damaging) effects of reactive species for the host.