Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Eggs in the balance.

M M Matzuk

    Nature Genetics
    |August 2, 2001
    PubMed
    Summary
    This summary is machine-generated.

    Polycyclic aromatic hydrocarbons (PAH) cause reproductive defects by activating the aryl hydrocarbon receptor (Ahr). This study reveals Ahr directly induces the Bax pathway in oocytes, mediating PAH toxicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Spermatogonial asynchrony in Tex14 mutant mice lacking intercellular bridges.

    Reproduction (Cambridge, England)·2020
    Same author

    Nine genes abundantly expressed in the epididymis are not essential for male fecundity in mice.

    Andrology·2019
    Same author

    Oocyte-somatic cell communication and microRNA function in the ovary.

    Annales d'endocrinologie·2010
    Same author

    The power of mouse genetics to study spermatogenesis.

    Journal of andrology·2009
    Same author

    Spermatogenesis does not require the local production of follistatin.

    Reproduction (Cambridge, England)·2006
    Same author

    Human cumulus granulosa cell gene expression: a predictor of fertilization and embryo selection in women undergoing IVF.

    Human reproduction (Oxford, England)·2004

    Area of Science:

    • Reproductive toxicology
    • Molecular toxicology
    • Ovarian biology

    Background:

    • Polycyclic aromatic hydrocarbons (PAH) are environmental toxicants found in cigarette smoke and air pollution.
    • PAH exposure is linked to reproductive defects, primarily through interaction with the aryl hydrocarbon receptor (Ahr).
    • Oocytes lacking Ahr or the pro-apoptotic protein Bax exhibit increased primordial follicle counts and resistance to PAH toxicity.

    Discussion:

    • The Bax promoter contains two core Ahr response elements (AhREs).
    • These AhREs are essential for PAH-induced stimulation of Bax promoter activity in oocytes.
    • This indicates a direct molecular mechanism for PAH-induced oocyte damage.

    Key Insights:

    • Aryl hydrocarbon receptor (Ahr) directly regulates the pro-apoptotic protein Bax in oocytes.

    Related Experiment Videos

  • Ahr response elements on the Bax promoter mediate PAH's toxic effects on oocytes.
  • The Ahr-Bax signaling axis is a critical pathway for PAH-induced reproductive toxicity.

    • Outlook:

    • Understanding the Ahr-Bax pathway may lead to targeted interventions against PAH-induced reproductive harm.
    • Further research could explore therapeutic strategies to protect oocytes from environmental toxicants.
    • Investigating AhREs in other oocyte-related genes could reveal additional mechanisms of PAH toxicity.