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[The relationship between angiogenesis and p53 overexpression in endometrioid adenocarcinoma]
Objective:
To determine the relationship between angiogenesis and p53 overexpression and explore the relationship between angiogenesis and clinicopathologic features in endometrioid adenocarcinoma.
Methods:
Angiogenesis was evaluated by intratumoral microvessel density (IMD). Eighty-five endometrioid adenocarcinomas' IMD were identified by immunohistochemical staining of endothelial cells for factor VIII-related antigen, and the expression of p53 protein was stained with the same method by it's monoclone antibody.
Results:
(1) The positive rate of p53 expression in endometrioid adenocarcinoma was 50.6%. The positive rate in stage III-IV (69.2%) was higher than that in stage I-II(42.4%) (P < 0.05). (2) IMD was higher in stage III-IV (13.27 +/- 6.14) than that in stage I-II (8.31 +/- 4.78) (P < 0.01). IMD in G1, G2 and G3 was 8.95 +/- 5.51, 9.28 +/- 4.87 and 14.73 +/- 7.66, respectively (P < 0.05). In groups of non-myoinvasion, < 1/2 myoinvasion and > or = 1/2 myoinvasion, IMD was 8.45 +/- 5.53, 8.95 +/- 4.99 and 11.96 +/- 6.39, respectively (P < 0.05). (3) In negative, weakly positive and strong positive groups of p53 overexpression, IMD was 5.52 +/- 2.11, 11.75 +/- 4.18 and 16.00 +/- 4.63, respectively (P < 0.01).
Conclusions:
Angiogenesis tightly correlated with clinicopathologic factors, such as stage, grade and myoinvasion, is promoted by p53 overexpression in endometrioid adenocarcinoma. It can be concluded that angiogenesis may act as a predictor of prognosis of endometrioid adenocarcinoma.