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The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
Published on: November 26, 2015
Use of the malleus handle as a landmark for localizing the round window membrane
H Silverstein1, B Durand, L E Jackson
1Ear Research Foundation, 1901 Floyd St., Sarasota, FL 34239, USA. hsilverste@aol.com
Abstract:
Localization of the round window membrane is desirable in order to allow a more direct application of medication to the inner ear. A new procedure has been developed to deliver direct, near-continuous inner ear perfusion to the round window with the Silverstein MicroWick. In this office procedure, the wick is inserted through a tympanostomy tube into the round window niche. Accurate localization of the round window is a necessary component of this procedure. In an effort to ascertain the precise location of the round window, we examined 25 cadaveric human temporal bones and measured the distance from the umbo to the round window in each sample. We found that the round window was an average of 3.44 mm (+/- 0.68) from the umbo and was situated at an average angle of 113.2 degrees (+/- 9.8) from the long process of the malleus. Our simple and reliable determination of the relationship between the malleus handle and the round window niche allows for the accurate placement of the Silverstein MicroWick and other devices.
Insights
Accurate placement of inner ear medication delivery devices like the Silverstein MicroWick is crucial. This study precisely mapped the round window
Area of Science:
- Otolaryngology
- Inner Ear Therapeutics
- Surgical Anatomy
Background:
- Direct application of medication to the inner ear via the round window is clinically desirable.
- The Silverstein MicroWick enables direct, near-continuous inner ear perfusion.
- Accurate localization of the round window is essential for successful device placement.
Purpose of the Study:
- To determine the precise anatomical relationship between the malleus handle and the round window niche.
- To provide reliable landmarks for accurate placement of the Silverstein MicroWick.
- To facilitate improved direct inner ear drug delivery.
Main Methods:
- Examination of 25 human cadaveric temporal bones.
- Measurement of the distance from the umbo to the round window.
- Determination of the angle from the long process of the malleus to the round window niche.
Main Results:
- The average distance from the umbo to the round window was 3.44 mm (+/- 0.68).
- The average angle from the long process of the malleus was 113.2 degrees (+/- 9.8).
- A simple and reliable method for locating the round window was established.
Conclusions:
- The established anatomical relationship between the malleus and the round window allows for accurate device placement.
- This anatomical data supports the precise insertion of the Silverstein MicroWick for inner ear perfusion.
- Improved localization techniques enhance the efficacy of direct inner ear medication delivery.
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