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Advanced heart block aggravated by carbamazepine
British Heart Journal
|June 1, 1975
Summary
Carbamazepine, an anticonvulsant, caused serious adverse reactions in a patient with Mobitz type II heart block. The drug induced ventricular standstill and Adams-Stokes attacks by impairing Purkinje fiber conduction.
Area of Science:
- Cardiology
- Pharmacology
- Neurology
Background:
- Carbamazepine is a widely used anticonvulsant medication.
- Mobitz type II atrioventricular block is a serious cardiac conduction abnormality.
- Syncope and Adams-Stokes attacks indicate severe bradyarrhythmias.
Purpose of the Study:
- To report a rare and serious adverse reaction to carbamazepine.
- To highlight the potential cardiotoxic effects of carbamazepine in patients with pre-existing conduction defects.
Main Methods:
- Case report detailing a patient's clinical presentation and hospital admission.
- Review of patient's cardiac rhythm and response to carbamazepine therapy.
Main Results:
- The patient experienced recurrent syncope due to Mobitz type II atrioventricular block.
- Carbamazepine administration led to suppressed conduction in Purkinje fibers.
- Ventricular standstill and Adams-Stokes attacks were induced by carbamazepine.
Conclusions:
- Carbamazepine can precipitate severe cardiac events in susceptible individuals.
- Caution is advised when prescribing carbamazepine to patients with cardiac conduction abnormalities.
- This case underscores the importance of monitoring cardiac function during carbamazepine treatment.
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