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CSF norepinephrine concentrations in posttraumatic stress disorder.

T D Geracioti1, D G Baker, N N Ekhator

  • 1Mental Health Service, Veterans Affairs Medical Center, 3200 Vine St., Cincinnati, OH 45220, USA. thomas.geracioti@med.va.gov

The American Journal of Psychiatry
|August 2, 2001
PubMed
Summary

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This study found higher central nervous system (CNS) norepinephrine levels in men with posttraumatic stress disorder (PTSD). Higher norepinephrine in cerebrospinal fluid (CSF) correlated with increased PTSD symptom severity.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Pharmacology

Background:

  • Posttraumatic stress disorder (PTSD) is linked to noradrenergic system hyperactivity.
  • Direct measurement of central nervous system (CNS) norepinephrine in PTSD has been limited.

Purpose of the Study:

  • To measure serial cerebrospinal fluid (CSF) norepinephrine levels in patients with PTSD.
  • To investigate the relationship between CNS norepinephrine and PTSD symptom severity.

Main Methods:

  • CSF samples were collected hourly over 6 hours from male combat veterans with PTSD and healthy controls.
  • Indwelling subarachnoid catheters were used for CSF collection.
  • PTSD symptom severity was assessed using the Clinician-Administered PTSD Scale.

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Main Results:

  • CSF norepinephrine concentrations were significantly elevated in individuals with PTSD compared to healthy controls.
  • CSF norepinephrine levels showed a strong positive correlation with PTSD symptom severity.
  • Plasma norepinephrine levels did not correlate significantly with PTSD symptom severity.

Conclusions:

  • Individuals with chronic PTSD exhibit increased CNS noradrenergic activity at baseline.
  • Elevated baseline CNS norepinephrine is directly associated with the severity of posttraumatic stress symptoms.