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Case report of pallido-pyramidal disease with supplementary motor area involvement
P F Pradat1, C Dupel-Pottier, L Lacomblez
1Fédération de Neurologie Mazarin, Hôpital de la Pitié-Salpétrière, Paris, France.
Abstract:
An C-flumazenil positron emission tomography (PET) study in a patient with pallido-pyramidal disease revealed a marked decrease in benzodiazepine-receptor density in the precentral gyrus cortex and the mesial frontal cortex. We suggest that, in addition to dysfunction of basal ganglia-dependent systems, degeneration of the supplementary motor area could also be involved in the patient's bradykinesia.