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[Dopamine in acute renal failure].

I Marai¹, Y Levi

¹Department of Medicine B, Center for Autoimmune Diseases, Chaim Sheba Medical Center, Tel-Hashomer.

|August 3, 2001

Summary

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Dopamine is not recommended for preventing or treating acute renal failure, despite its common use. Current evidence shows no benefit and highlights potential side effects, suggesting its avoidance in clinical practice.

Area of Science:

Nephrology
Pharmacology

Context:

Dopamine is frequently utilized for acute renal failure prevention and treatment.
Its use is often based on presumed selective renal effects at low doses.

Purpose:

To evaluate the efficacy and safety of dopamine in preventing and treating acute renal failure.
To determine if dopamine offers benefits in high-risk procedures or established acute renal failure.

Summary:

Evidence does not support dopamine's use in preventing acute renal failure during high-risk procedures.
Most studies indicate a lack of benefit for dopamine treatment in patients with acute renal failure.
Dopamine is associated with known adverse effects.

Impact:

The findings suggest that dopamine use for acute renal failure should be avoided.

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Further large randomized controlled trials are needed to clarify outcomes like mortality, dialysis need, and hospitalization duration.