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Related Experiment Videos

Development of an implantable artificial lung: challenges and progress.

J B Zwischenberger1, C M Anderson, K E Cook

  • 1Division of Cardiothoracic Surgery, The University of Texas Medical Branch, Galveston 77555, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 3, 2001
PubMed
Summary

Researchers are developing an ambulatory artificial lung to support adults with respiratory failure. This device aims to serve as a crucial bridge to lung transplantation and aid post-transplant recovery.

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Area of Science:

  • Biomedical Engineering
  • Respiratory Physiology
  • Transplantation Medicine

Background:

  • Current treatments like dialysis and ventricular assist devices serve as bridges to organ transplantation, but no equivalent exists for lung transplantation.
  • Severe respiratory failure necessitates advanced support beyond conventional mechanical ventilation.

Purpose of the Study:

  • To design and construct an ambulatory artificial lung capable of full metabolic support for adults.
  • To create a device that can be perfused by the right ventricle, acting as a bridge to lung transplantation.

Main Methods:

  • Focus on artificial lung design and integration with the pulmonary circulation.
  • Investigating both intracorporeal and paracorporeal placement options for the device.
  • Ensuring the device can fully support oxygen (O2) and carbon dioxide (CO2) exchange.

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Main Results:

  • The study outlines the design goals for an ambulatory artificial lung.
  • The device is intended for complete metabolic support, perfusable by the right ventricle.
  • Research is exploring optimal device placement and circulatory integration.

Conclusions:

  • An ambulatory artificial lung could significantly impact lung transplantation as a bridge therapy.
  • The device may also serve as post-lung transplant support or a rescue therapy for severe respiratory failure.
  • Further research into artificial lung design and implementation is crucial for clinical application.