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Related Experiment Videos

Continuous venovenous renal replacement therapy using a conventional infusion pump.

C Sánchez1, J López-Herce, E García

  • 1Pediatric Intensive Care Unit and Experimental Medicine, Gregorio Marañón University Hospital, Madrid, Spain.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 3, 2001
PubMed
Summary

Continuous venovenous hemofiltration and hemodiafiltration using a standard infusion pump proved safe and effective in a pediatric animal model. This method offers a viable alternative for neonatal and infant extrarenal replacement therapy.

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Area of Science:

  • Pediatric Nephrology
  • Critical Care Medicine
  • Biomedical Engineering

Background:

  • Neonates and infants often require extrarenal replacement therapy (ERT) for acute kidney injury.
  • Conventional ERT methods can be complex and resource-intensive for pediatric patients.
  • Evaluating alternative, accessible ERT techniques is crucial for improving outcomes.

Purpose of the Study:

  • To assess the feasibility and safety of continuous venovenous hemofiltration (CVVH) and continuous venovenous hemodiafiltration (CVVHDF) using a conventional infusion pump in a pediatric animal model.
  • To compare the efficacy of CVVH and CVVHDF with this adapted technique.

Main Methods:

  • Fourteen pediatric pigs (8-13 kg) underwent CVVH and CVVHDF for 1 hour each.
  • A standard infusion pump (IVAC 571) and a pediatric hemofilter (0.22 m2) were utilized.

Related Experiment Videos

  • Ringer's solution served as both dialysate and replacement fluid; physiological parameters were monitored.

    • Main Results:

    • No significant changes in heart rate, blood pressure, hematocrit, electrolytes, or pH were observed.
    • Mean ultrafiltrate flow rates were comparable between CVVH and CVVHDF.
    • Circuit pressure increased significantly over the 2-hour experiment (107.7 to 234.2 mm Hg, p < 0.05), but the technique was well-tolerated.

    Conclusions:

    • Continuous venovenous hemofiltration and hemodiafiltration with a conventional infusion pump is a safe and feasible alternative for pediatric ERT.
    • This adapted technique demonstrates potential for use in neonates and infants, offering a more accessible treatment option.