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Chordoid meningioma. A case report.
1Department of Neurosurgery, Mito Saiseikai General Hospital, Ibaraki, Japan.
Pathology, Research and Practice
|August 3, 2001
Summary
This study describes a rare chordoid meningioma in a 62-year-old woman. The brain tumor exhibited unique cellular features and immunohistochemical markers, aiding in its diagnosis.
Area of Science:
- Neuropathology
- Neurosurgery
- Oncology
Background:
- Meningiomas are tumors arising from the meninges.
- Chordoid meningioma is a rare subtype with distinct histological features.
- Accurate diagnosis is crucial for appropriate patient management.
Observation:
- A 62-year-old woman presented with a parietal lobe brain tumor.
- The encapsulated tumor adhered to the dura and was separated from the cerebrum.
- Histopathology revealed a multilobular tumor composed of myxomatous and meningothelial cells.
Findings:
- The myxomatous cells, comprising four-fifths of the tumor, showed a chordoma-like pattern within a myxoid stroma.
- Meningothelial cells with eosinophilic cytoplasm and periodic acid-Schiff positive material were also present.
- Immunohistochemistry showed positivity for vimentin and Leu-7 (CD57), and negativity for epithelial membrane antigen, S-100 protein, and cytokeratin.
Implications:
- This case highlights the diagnostic challenges and histological variability of chordoid meningioma.
- Understanding the immunohistochemical profile aids in differentiating it from other neoplasms.
- Further research may elucidate the specific behavior and optimal treatment strategies for this rare meningioma subtype.