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Related Experiment Videos

Chordoid meningioma. A case report.

S Mori1, K Oka, H Hakozaki

  • 1Department of Neurosurgery, Mito Saiseikai General Hospital, Ibaraki, Japan.

Pathology, Research and Practice
|August 3, 2001
PubMed
Summary

This study describes a rare chordoid meningioma in a 62-year-old woman. The brain tumor exhibited unique cellular features and immunohistochemical markers, aiding in its diagnosis.

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Area of Science:

  • Neuropathology
  • Neurosurgery
  • Oncology

Background:

  • Meningiomas are tumors arising from the meninges.
  • Chordoid meningioma is a rare subtype with distinct histological features.
  • Accurate diagnosis is crucial for appropriate patient management.

Observation:

  • A 62-year-old woman presented with a parietal lobe brain tumor.
  • The encapsulated tumor adhered to the dura and was separated from the cerebrum.
  • Histopathology revealed a multilobular tumor composed of myxomatous and meningothelial cells.

Findings:

  • The myxomatous cells, comprising four-fifths of the tumor, showed a chordoma-like pattern within a myxoid stroma.
  • Meningothelial cells with eosinophilic cytoplasm and periodic acid-Schiff positive material were also present.

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  • Immunohistochemistry showed positivity for vimentin and Leu-7 (CD57), and negativity for epithelial membrane antigen, S-100 protein, and cytokeratin.

    • Implications:

    • This case highlights the diagnostic challenges and histological variability of chordoid meningioma.
    • Understanding the immunohistochemical profile aids in differentiating it from other neoplasms.
    • Further research may elucidate the specific behavior and optimal treatment strategies for this rare meningioma subtype.