Related Experiment Videos
An expeditious approach toward the total synthesis of CP-263,114
J T Njardarson1, I M McDonald, D A Spiegel
1Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
Organic Letters
|August 3, 2001
Abstract:
[reaction: see text] Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and the late-stage fragmentation of a densely functionalized isotwistane skeleton.