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Related Experiment Videos

Two telomerase reverse transcriptases (TERTs) expressed in Candida albicans.

A M Metz1, R A Love, G A Strobel

  • 1Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA.

Biotechnology and Applied Biochemistry
|August 3, 2001
PubMed
Summary

Researchers identified two telomerase reverse transcriptase (TERT) genes in the human pathogenic yeast Candida albicans. These findings offer the first chance to study telomerase in this significant pathogen.

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Area of Science:

  • Molecular Biology
  • Mycology
  • Genetics

Background:

  • * *Candida albicans* is a significant human pathogenic yeast.
  • * Telomerase is a crucial enzyme for maintaining chromosome ends (telomeres).
  • * Understanding telomerase in *C. albicans* is vital for pathogen research.

Purpose of the Study:

  • * To identify and characterize telomerase reverse transcriptase (TERT) genes in *Candida albicans*.
  • * To provide foundational data for studying telomerase function in this pathogen.

Main Methods:

  • * Bioinformatic analysis to identify TERT gene candidates.
  • * Sequence comparison with known TERT proteins, including *Saccharomyces cerevisiae* Est2p.
  • * Analysis of protein properties (size, pI, molecular weight).

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Main Results:

  • * Two distinct TERT genes, CaTERT1 and CaTERT2, were identified in *C. albicans*.
  • * These genes encode small 867-residue proteins, the smallest TERTs reported to date.
  • * Both CaTERT1 and CaTERT2 genes appear to be expressed and potentially encode proteins differing by five amino acids.
  • * A revised alignment for motif E of the *S. cerevisiae* orthologue Est2p was proposed based on CaTERT1 similarity.

Conclusions:

  • * The discovery of CaTERT1 and CaTERT2 provides the first molecular tools to investigate telomerase in *Candida albicans*.
  • * These findings lay the groundwork for future studies on telomere maintenance and potential therapeutic targets in this important human pathogen.