Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal hemoglobin synthesis in some leukemic patients.

J Pagnier, D Labie

    Biochimie
    |January 1, 1975
    PubMed
    Summary

    Leukemia disrupts hemoglobin synthesis, increasing beta chains and free alpha chains. This suggests complex regulatory defects beyond simple messenger RNA reduction in fetal hemoglobin patients.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Foetal haemoglobin, erythrocytes containing foetal haemoglobin, and hematological features in congolese patients with sickle cell anaemia.

    Anemia·2012
    Same author

    [The problem of sickle cell disease in Africa].

    Medecine tropicale : revue du Corps de sante colonial·2011
    Same author

    Education status among orphans and non-orphans in communities affected by AIDS in Tanzania and Burkina Faso.

    AIDS care·2008
    Same author

    Two novel CD1 E alleles identified in black African individuals.

    Tissue antigens·2002
    Same author

    Additive effects of beta chain mutations in low oxygen affinity hemoglobin betaF41Y,K66T.

    The Journal of biological chemistry·1999
    Same author

    Genetic variations in human fetal globin gene microsatellites and their functional relevance.

    Human genetics·1999

    Area of Science:

    • Hematology
    • Molecular Biology
    • Oncology

    Background:

    • Leukemic processes can affect normal cellular functions, including protein synthesis.
    • Fetal hemoglobin (HbF) persistence in adults is associated with certain hematological conditions.
    • Understanding hemoglobin chain synthesis is crucial for diagnosing and managing blood disorders.

    Purpose of the Study:

    • To investigate hemoglobin chain synthesis patterns in leukemic patients with fetal hemoglobin.
    • To identify specific abnormalities in alpha and beta globin chain production.
    • To explore potential mechanisms underlying these synthesis defects.

    Main Methods:

    • Analysis of hemoglobin chain synthesis in patient samples.
    • Quantification of globin chain precursors.
    • Assessment of messenger RNA levels (implied).

    Main Results:

    • Increased synthesis of the beta globin chain was observed.
    • A significant increase in free dimeric precursors, predominantly alpha chains, was found.
    • Observed abnormalities suggest a mechanism more complex than reduced messenger RNA.

    Conclusions:

    • The findings indicate potential alpha-thalassemia-like features alongside more complex regulatory issues.
    • A defect in alpha chain-dependent regulation is a plausible explanation for the observed abnormalities.
    • The role of clonal disorders in these synthesis defects remains undetermined.

    Related Experiment Videos