The relation between osmotic flow and tracer solvent diffusion for single-file transport
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Updated: Aug 19, 2026

A Simple, Robust, and High Throughput Single Molecule Flow Stretching Assay Implementation for Studying Transport of Molecules Along DNA
Published on: October 1, 2017
Abstract:
It is demonstrated that a reasonably general model for single-file passage of solvent through an ultra-narrow pore implies the equality of tracer diffusion and osmotic flow. This result is not trival, but follows from the exactly compensating effects of solvent-solvent interaction on the paritioning of bulk solvent into the pore and on the diffusion rate within the pore. A previous calculation of Longuet-Higgins and Austin is seen to be valid only in the absence of interactions among solvent molecules in the pore.
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