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Updated: Jul 23, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
Published on: July 1, 2013
Interleukin-8 stimulates human immunodeficiency virus type 1 replication and is a potential new target for
1Divisions of Infectious Diseases, University of Michigan Medical Center, Ann Arbor, Michigan 48109-0640, USA.
Abstract:
Production of the C-X-C chemokines interleukin-8 (IL-8) and growth-regulated oncogene alpha (GRO-alpha) in macrophages is stimulated by exposure to human immunodeficiency virus type 1 (HIV-1). We have demonstrated previously that GRO-alpha then stimulates HIV-1 replication in both T lymphocytes and macrophages. Here we demonstrate that IL-8 also stimulates HIV-1 replication in macrophages and T lymphocytes. We further show that increased levels of IL-8 are present in the lymphoid tissue of patients with AIDS. In addition, we demonstrate that compounds which inhibit the actions of IL-8 and GRO-alpha via their receptors, CXCR1 and CXCR2, also inhibit HIV-1 replication in both T lymphocytes and macrophages, indicating potential therapeutic uses for these compounds in HIV-1 infection and AIDS.
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