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[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs]
1Department of Medicine, Hu Guo Si Hospital of Traditional Chinese Medicine Affliated to Beijing Traditional Chinese Medicine and Materia Medical University,Beijing 100035 P.R.China.
Objective:
To analyze the hereditary susceptibility for HLA-DQA1 alleles according to trait of multiple genes leading to disease in atherothrombotic brain infarction (ABI).
Methods:
HLA-DQA1 alleles in ABI patients (n=81) and healthy controls (n=99) were detected by PCR-SSP techniques.
Results:
(1)The frequency of HLA-DQA1*0301 was significantly higher in ABI patients. (2)The frequency of HLA-DQA1*0301 was significantly higher in patients with family history of essential hypertension (EH). (3)The frequency of HLA-DQA1*0103 was significantly lower in ABI patients.
Conclusion:
HLA-DQA1*0301 allele might be a correlative gene with hereditary susceptibility of ABI and HLA-DQA1*0301 allele might be a correlative gene in ABI patients with the family history of essential hypertension, whereas HLA-DQA1*0103 allele might be a protective gene in the patients with ABI.