Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Human thymic dendritic cells].

A H Dalloul1

  • 1URA CNRS 625, CERVI, hôpital de la Pitié, boulevard de l'Hôpital, 75651 Paris, France.

Pathologie-Biologie
|August 4, 2001
PubMed
Summary

Human thymus contains two distinct dendritic cell (DC) populations: lymphoid and myeloid. Their specific roles in immune tolerance require further investigation to understand central tolerance mechanisms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of mature and immature human thymic dendritic cells that differentially express HLA-DR and interleukin-3 receptor in vivo.

Journal of leukocyte biology·2000
Same author

Functional and phenotypic analysis of thymic CD34+CD1a- progenitor-derived dendritic cells: predominance of CD1a+ differentiation pathway.

Journal of immunology (Baltimore, Md. : 1950)·1999
Same author

Theophylline-induced B-CLL apoptosis is partly dependent on cyclic AMP production but independent of CD38 expression and endogenous IL-10 production.

Leukemia·1999
Same author

Human CD34(+) thymocyte maturation: pre-T and NK cell differentiation on neonatal thymic stromal cell culture.

Cellular immunology·1998
Same author

Adoptively transferred CD4+ lymphocytes from CD8 -/- mice are sufficient to mediate the rejection of MHC class II or class I disparate skin grafts.

Journal of immunology (Baltimore, Md. : 1950)·1996
Same author

CD4-negative cytotoxic T cells with a T cell receptor alpha/beta intermediate expression in CD8-deficient mice.

European journal of immunology·1996

Area of Science:

  • Immunology
  • Cell Biology

Context:

  • Human thymic dendritic cells (DCs) are crucial for immune regulation.
  • Previous research suggests thymic DCs play a role in central tolerance induction.

Purpose:

  • To characterize distinct human thymic dendritic cell populations.
  • To investigate their potential lymphoid or myeloid lineage and maturity markers.

Summary:

  • Two main human thymic DC subsets were identified: a CD4+ CD45RA+ CD33-CD11c- lymphoid-like population (immature) and a CD4+ CD33+ CD11c+ myeloid population (mature).
  • Both subsets can be generated from CD34+ progenitors in vitro.
  • The lymphoid-like subset expresses CD123 and pre-TCR-alpha transcripts, suggesting a link to interferon-producing cells.

Impact:

  • This research differentiates human thymic DC subsets, providing a basis for studying their distinct functions.
  • Understanding these subsets is critical for elucidating mechanisms of central tolerance in the human thymus.

Related Experiment Videos