Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dendritic cells and hepatitis C virus].

C Bain1, G Inchauspé

  • 1Unité inserm 271, 151, cours Albert Thomas, 69003 Lyon, France.

Pathologie-Biologie
|August 4, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recognition of Core- and Polymerase-derived immunogenic peptides included in novel therapeutic vaccine by T cells from Chinese chronic hepatitis B patients.

Journal of viral hepatitis·2017
Same author

Consumption of sugar-sweetened beverages and type 2 diabetes incidence in Thai adults: results from an 8-year prospective study.

Nutrition & diabetes·2017
Same author

Venous flaps for coverage of traumatic soft tissue defects of the hand: a systematic review.

The Journal of hand surgery, European volume·2017
Same author

Patient and community attitudes toward perioperative biobanking and genomic research.

Anaesthesia and intensive care·2017
Same author

T- and B-cell responses to multivalent prime-boost DNA and viral vectored vaccine combinations against hepatitis C virus in non-human primates.

Gene therapy·2016
Same author

A prospective randomised controlled trial comparing tracheal intubation plus manual in-line stabilisation of the cervical spine using the Macintosh laryngoscope vs the McGrath(®) Series 5 videolaryngoscope.

Anaesthesia·2014

Hepatitis C virus (HCV) RNA is found in B cells and monocytes-derived dendritic cells (DCs). In patients with chronic HCV, these cells show altered function, but therapy restores their capacity.

Area of Science:

  • Virology
  • Immunology
  • Hepatology

Context:

  • Hepatitis C virus (HCV) infection leads to chronic illness and hepatocellular carcinoma.
  • HCV RNA presence in hematopoietic cells is not fully understood.
  • Investigating immune cell involvement in persistent HCV infection is crucial.

Purpose:

  • To detect Hepatitis C virus genomic RNA in hematopoietic cells.
  • To assess the function of B cells and dendritic cells (DCs) in HCV patients.
  • To evaluate the impact of therapy on immune cell function in HCV responders.

Summary:

  • HCV genomic RNA was identified in B cells and monocyte-derived dendritic cells (DCs).
  • The allostimulatory capacity of these DCs was impaired in patients with chronic HCV.

Related Experiment Videos

  • This function was restored in individuals who responded long-term to therapy.

    • Impact:

    • Identifies specific immune cells harboring HCV RNA.
    • Reveals functional deficits in antigen-presenting cells during chronic HCV.
    • Suggests immune restoration following successful HCV treatment.