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Hypertonic-hyperoncotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine
1Institute for Clinical Chemistry, Klinikum Mannheim gGmbH, Faculty of Clinical Medicine Mannheim of the University of Heidelberg, Germany. thomas.bertsch@ikc.ma.uni-heidelberg.de
Abstract:
In this study we addressed the question of whether the measurement of cardiac Troponin I (cTnI) is able to reflect beneficial effects of hypertonic-hyperoncotic solutions after transient cardiac arrest. Ten pigs were anaesthetized and cardiac arrest was induced by electric fibrillation. After 5 minutes of global ischemia, cardiac arrest was reversed by electric defibrillation. Upon return of spontaneous circulation 5 animals received hypertonic-hyperoncotic solutions (10% Hydroxyethylstarch 200/0.5 and 7.2% NaCl). The other animals received equivalent volumes of physiological saline. We observed that cTnI serum levels of animals treated with hypertonic-hyperoncotic solutions were significantly lower than those treated with saline. We conclude that hypertonic-hyperoncotic solutions may have cardioprotective effects.