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Related Experiment Videos

Prolonged drip-infusion cholangiography.

W A Fuchs, R Preisig

    The British Journal of Radiology
    |July 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    This study estimated the transport maximum (TM) for ioglycamide in humans, finding it beneficial for contrast-enhanced cholangiography in patients with liver dysfunction. Slow infusion above the TM improved imaging success rates in obstructive and hepatocellular diseases.

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    Area of Science:

    • Radiology
    • Hepatology
    • Pharmacokinetics

    Background:

    • Hepatic excretion of iodipamide and ioglycamide is limited by a transport maximum (TM) in animal models.
    • Excess contrast doses exceeding the TM are primarily excreted renally.

    Purpose of the Study:

    • To estimate the TM for ioglycamide in humans.
    • To evaluate the efficacy of prolonged, slow-dose contrast administration above the TM in patients with impaired liver function undergoing cholangiography.

    Main Methods:

    • Human TM estimation for ioglycamide using indwelling T-tubes.
    • Slow overnight infusion of ioglycamide (35 mg/minute) in patients with previously unsuccessful standard cholangiography.
    • Assessment of contrast filling in obstructive and hepatocellular liver disease.

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    Main Results:

    • Human TM for ioglycamide was determined to be 19-23 mg/minute.
    • A 75% overall success rate was achieved with the slow infusion method.
    • Similar improvements in imaging were observed in both obstructive and hepatocellular disease groups.

    Conclusions:

    • Prolonged infusion of ioglycamide slightly above the human TM can enhance cholangiography in patients with impaired liver function.
    • This method offers advantages for ductal filling in obstruction and gallbladder concentration in hepatocellular disease.
    • Slow overnight infusion represents a viable alternative for challenging cholangiography cases.