Related Experiment Video
Updated: Jun 21, 2026

Pulse-chase Analysis of N-linked Sugar Chains from Glycoproteins in Mammalian Cells
Published on: April 28, 2010
Protein synthesis. The perks of balancing glucose
Abstract:
What do the regulation of translation initiation and glucose metabolism have to do with each other? Quite a lot, it seems, according to Sonenberg and Newgard in their Perspective. They discuss new findings that identify the kinase responsible for inactivating eIF2--a factor that is required for translation initiation (and hence protein synthesis)--when the endoplasmic reticulum is under stress. Loss of this kinase results in destruction of insulin-producing b cells in the pancreas and dysregulation of glucose homeostasis.
Related Concept Videos
Protein and Protein Structure
A protein's shape is critical to its function. For example, an enzyme can...
Protein Glycosylation
Glycosylation occurs in...
Sugars as Energy Storage Molecules
Sugars as Energy Storage Molecules
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
Biosynthesis of Polysaccharides

