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Follicular dendritic cell tumor presenting in the lung: a case report
R N Shah1, O Ozden, A Yeldandi
1Department of Pathology, Northwestern University Medical School, Chicago, IL, USA.
Human Pathology
|August 4, 2001
Summary
This case report describes follicular dendritic cell sarcoma (FDCS) in the lung, an unusual location. Immunohistochemistry, including CD21 and CD35 markers, aids diagnosis of this rare tumor.
Area of Science:
- Oncology
- Pathology
Background:
- Follicular dendritic cell sarcoma (FDCS) is a rare malignant neoplasm of follicular dendritic cells.
- Extranodal involvement is common, but presentation in the lung is uncommon.
Observation:
- A 9.5-cm dominant mass with smaller nodules in the lung parenchyma and pleura was observed.
- Microscopic examination revealed spindled cells with lymphocytes and plasma cells.
- Immunohistochemistry showed expression of CD21 and CD35, with negative markers for keratin, CD45, CD20, S-100, muscle-specific actin, and gp100.
Findings:
- The study describes an extranodal follicular dendritic cell sarcoma (FDCS) presenting in the lung.
- The tumor exhibited characteristic immunohistochemical markers (CD21+, CD35+) and ultrastructural features.
- Epstein-Barr virus (EBV) was not detected in the tumor cells.
Implications:
- FDCS should be considered in the differential diagnosis of lung tumors with spindled morphology and inflammatory cells.
- Immunohistochemical analysis, particularly CD21 and CD35, is crucial for diagnosing FDCS, especially in small biopsy samples.
- This case highlights the importance of considering rare diagnoses in unusual locations.