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High-dose treatment with autologous stem cell transplantation versus sequential chemotherapy: the GELA experience
A Bosly1, C Haioun, C Gisselbrecht
1Mont-Godinne University Hospital, Yvoir, Belgium. andre.bosly@sang.ucl.ac.be
Abstract:
Autologous stem-cell transplantation (ASCT) has permitted to deliver high-dose therapy (HDT). In aggressive lymphomas, the GELA group conducted prospective and retrospective studies comparing HDT + ASCT to conventional sequential chemotherapy. In relapsing patients and in partial remission, retrospective studies showed a survival advantage for HDT + ASCT over sequential chemotherapy. In complete response, advantage for HDT + ASCT was demonstrated in a prospective trial only for patients with high intermediate or high risk in the IPI score. The attainment of a maximal reduction of the tumoral mass before going HDT is very important either in first line or in relapsing patients.
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