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[Pseudoallergies].

R Bernardini1, E Novembre, E Lombardi

  • 1Clinica Pediatrica III, Azienda Meyer, Centro di Allergologia e Broncopneumologia Pediatrica, Dipartimento di Pediatria, Università di Firenze, Via Luca Giordano, 13, 50132 Firenze, Italia.

La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics
|August 7, 2001
PubMed
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Pseudo-allergic reactions (PAR) manifest as various symptoms like urticaria and asthma, affecting a wide range of individuals. These non-immunologically mediated reactions are triggered by foods, additives, or drugs and are treated similarly to allergic conditions.

Area of Science:

  • Clinical immunology
  • Pharmacology
  • Gastroenterology

Context:

  • Pseudo-allergic reactions (PAR) present with diverse clinical symptoms including urticaria, angioedema, rhinitis, asthma, and anaphylaxis.
  • The prevalence of PAR varies significantly across studies, ranging from 0.1% to 75%.
  • PAR pathogenesis is non-immunologically mediated, distinguishing them from true allergic responses.

Purpose:

  • To delineate the clinical characteristics, prevalence, pathogenetic mechanisms, diagnostic criteria, and treatment strategies for pseudo-allergic reactions (PAR).
  • To differentiate PAR from IgE-mediated allergic diseases through diagnostic testing.
  • To outline therapeutic approaches for managing PAR.

Summary:

  • PAR encompass a spectrum of clinical manifestations such as urticaria, angioedema, and asthma, triggered by common exposures like food, additives, and drugs.

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  • Diagnosis relies on the absence of specific IgE antibodies and confirmation through in vitro and in vivo tests, excluding immunological mechanisms.
  • Treatment protocols for PAR mirror those for allergic diseases, involving antihistamines, steroids, B2 agonists, and epinephrine.

    • Impact:

    • Provides a comprehensive overview of PAR, aiding clinicians in accurate diagnosis and management.
    • Highlights the importance of distinguishing PAR from allergic reactions to ensure appropriate patient care.
    • Informs therapeutic strategies for a condition with a broad prevalence and varied clinical presentations.