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Prospecting Microbial Strains for Bioremediation and Probiotics Development for Metaorganism Research and Preservation
Published on: October 31, 2019
Cytotoxic bicyclic diterpene from the brown alga Sargassum crispum
S E Ayyad1, M O Slama, A H MoKhtar
1Chem. Dept., Damiatta Faculty of Science-Mansoura University, Mansoura, Egypt.
Abstract:
Study of the brown alga Sargassum crispum collected from Red Sea resulted in the isolation of new diterpene with hydroazulene skeleton, Sargassinone (6), some fatty acids ethyl ester andsome fatty acids. The identification of the isolated metabolites was established mainly by spectral methods and chemical transformation of sargassinone (6) to its acetate (7). The two diterpens (6, 7) exhibited substantial cytotoxic activities, as indicated by their IC50 values at the dose of 10 micrograms/ml or less.
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