Related Experiment Video
Updated: Aug 3, 2026

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
Published on: February 7, 2017
Comparison of monomeric and polymeric amino acid based surfactants for chiral separations
F H Billiot1, E J Billiot, I M Warner
1Department of Chemistry, Louisiana State University, Baton Rouge 70803, USA.
Abstract:
To better understand chiral recognition with polymeric amino acid based surfactants, the chromatographic performance of 18 monomeric and polymeric surfactants were compared for chiral analytes with various charge states and hydrophobicities. In this study, four amino acids (glycine, L-alanine, L-valine, and L-leucine) were chosen, and all possible combinations of the chiral single amino acid and dipeptide surfactants were synthesized. The results indicate that polymeric surfactants usually provide better chiral resolution for enantiomers of lorazepam, temazepam, 1,1'-bi-2-naphthol, and propranolol as compared to monomeric surfactants. In contrast, monomers perform better for chiral recognition of the 1,1'-bi-2-naphthyl-2,2'-diyl hydrogenphosphate enantiomers.
Related Concept Videos
Detergent Purification of Membrane Proteins
Racemic Mixtures and the Resolution of Enantiomers
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Ion Exchange
Surface Active Agents
Micelles

