Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet collagen receptors.

K J Clemetson1, J M Clemetson

  • 1Theodor Kocher Institute, University of Berne, Switzerland. clemetson@tki.unibe.ch

Thrombosis and Haemostasis
|August 7, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Distinct effects of Re- and S-forms of LPS on modulating platelet activation.

Journal of thrombosis and haemostasis : JTH·2013
Same author

Potential therapeutic targeting of platelet-mediated cellular interactions in atherosclerosis and inflammation.

Current medicinal chemistry·2011
Same author

The role of platelets in defence against pathogens.

Hamostaseologie·2011
Same author

Classification and nomenclature of snake venom C-type lectins and related proteins.

Toxicon : official journal of the International Society on Toxinology·2009
Same author

Scientific and standardization committee communications: classification and nomenclature of snake venom C-type lectins and related proteins.

Journal of thrombosis and haemostasis : JTH·2008
Same author

Snake venom C-type lectins as tools in platelet research.

Platelets·2006
Same journal

Discontinuation of Oral Anticoagulation After Successful Catheter Ablation for Atrial Fibrillation: Meta-analysis of Randomized Clinical Trials.

Thrombosis and haemostasis·2026
Same journal

Novel/Recurrent Variants in Pakistani Glanzmann Thrombasthenia and Glanzmann-like bleeding diathesis: Insights from NGS Analysis.

Thrombosis and haemostasis·2026
Same journal

Anti-TFPI Single-Domain Antibodies: Novel Rebalancing Therapies for Hemophilia and Other Rare Bleeding Disorders.

Thrombosis and haemostasis·2026
Same journal

The Interaction of Fibrin with Endothelial Cell Receptor N-Cadherin Promotes Fibrin-Dependent Angiogenesis.

Thrombosis and haemostasis·2026
Same journal

Antiphospholipid Antibodies and Atrial Fibrillation: Clinical Implications and the TaPL AF Study Design.

Thrombosis and haemostasis·2026
Same journal

Prasugrel vs. Ticagrelor: Can TUXEDO-2 Settle the Debate?

Thrombosis and haemostasis·2026
See all related articles

Collagen interactions with platelets are crucial for hemostasis and thrombosis. This review explores how platelet receptors like integrin alpha2beta1, GPVI, and GPIb-V-IX mediate these interactions, aiding in developing new antithrombotic therapies.

Area of Science:

  • Biochemistry
  • Hematology
  • Pharmacology

Background:

  • Collagens in the vascular subendothelium are potent platelet activators.
  • Regulating platelet activation is key to differentiating normal hemostasis from pathological thrombosis.
  • Collagen-platelet interactions are critical targets for pharmacological intervention.

Purpose of the Study:

  • To review the known platelet receptors for collagen.
  • To discuss the distinct and collaborative roles of these receptors in platelet activation.
  • To explore the mechanisms underlying collagen-mediated platelet responses.

Main Methods:

  • Literature review of collagen-platelet interactions.
  • Analysis of the roles of integrin alpha2beta1, GPVI, and GPIb-V-IX.

Related Experiment Videos

  • Discussion of proposed mechanisms for receptor cooperation.

    • Main Results:

    • Platelets possess multiple collagen receptors, including integrin alpha2beta1, GPVI, and GPIb-V-IX.
    • These receptors mediate distinct functions: adhesion, signaling, and interaction at high shear rates.
    • The synergistic action of these receptors in response to collagen is complex and not fully understood.

    Conclusions:

    • Understanding collagen receptor function is vital for developing targeted antithrombotic agents.
    • Further research is needed to elucidate the precise mechanisms of cooperative receptor action.
    • Pharmacological control of collagen-platelet pathways offers therapeutic potential for thrombotic disorders.