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Pyogenic cocci in infantile eczema throughout one year
British Medical Journal
|July 26, 1975
Summary
Staphylococci causing sepsis in infantile eczema originate from persistent skin and nose colonization. Streptococci causing sepsis are new infections, often from external sources, and topical antibiotics are ineffective against these resistant bacteria.
Area of Science:
- Microbiology
- Dermatology
- Pediatrics
Background:
- Infantile eczema patients are susceptible to bacterial sepsis.
- Identifying the source of pyococci is crucial for preventing sepsis attacks.
Purpose of the Study:
- To determine the origin of staphylococci and streptococci causing sepsis in infantile eczema.
- To assess the effectiveness of topical antibiotics in preventing recurrent sepsis.
Main Methods:
- Longitudinal study of 20 infantile eczema patients over one year.
- Regular sampling of skin, nose, throat, and family contacts.
- Phage typing for staphylococci and serological typing for streptococci.
Main Results:
- Staphylococci causing sepsis originated from persistent colonization sites (skin, nose).
- Streptococci causing sepsis were new infections, sometimes from patient or contact throat infections.
- Antibiotic resistance (neomycin, sodium fusidate, gentamicin) was observed in both staphylococci and streptococci.
Conclusions:
- Staphylococcal sepsis in infantile eczema arises from endogenous reservoirs.
- Streptococcal sepsis is due to exogenous reinfection, highlighting the need for source control.
- Topical antibiotics have limited efficacy in preventing sepsis due to bacterial resistance.
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