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Hyperglycemia and cardiovascular disease.

W C Duckworth1

  • 1Diabetes Research, VA Medical Center, 650 E. Indian School Road, Phoenix, AZ 85012, USA. william.duckworth@med.va.gov

Current Atherosclerosis Reports
|August 7, 2001
PubMed
Summary

Hyperglycemia

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Area of Science:

  • Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Type 2 diabetes presents numerous microvascular and macrovascular complications.
  • The role of hyperglycemia in macrovascular complications is debated, especially in type 2 diabetes.
  • Macrovascular issues in type 2 diabetes can precede significant hyperglycemia.

Purpose of the Study:

  • To investigate the unclear and controversial role of hyperglycemia in macrovascular complications.
  • To explore the association between glucose elevations and macrovascular disease progression in type 2 diabetes.
  • To identify mechanisms linking hyperglycemia to cardiovascular disease.

Main Methods:

  • Review of existing literature on hyperglycemia and macrovascular complications.
  • Analysis of metabolic abnormalities in type 2 diabetes.
  • Examination of proposed biochemical pathways linking hyperglycemia to cardiovascular disease.

Main Results:

  • A clear association between glucose levels and macrovascular complications is not consistently shown.
  • Postprandial glucose elevations show some association with macrovascular disease.
  • Mechanisms like sorbital pathway activation, oxidative stress, and advanced glycation endproducts (AGEs) are implicated.

Conclusions:

  • Hyperglycemia's role in macrovascular complications is significant but not fully defined.
  • Endothelial dysfunction, altered protein function, and increased cytokine production are potential consequences.
  • Ongoing studies aim to clarify hyperglycemia's impact on cardiovascular disease in type 2 diabetes.

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