Did the antioxidant trials fail to validate the oxidation hypothesis?
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Updated: Oct 5, 2026

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
S Parthasarathy1, N Khan-Merchant, M Penumetcha
1Department of Gynecology and Obstetrics, Emory University, 1639 Pierce Drive, #4300 WMB, Atlanta, GA 30322, USA. spartha@emory.edu
Abstract:
Most clinical trials on antioxidants using vitamin E or beta-carotene have failed to note any significant change in cardiovascular endpoints. The results of these studies have been interpreted as a setback for the oxidation hypothesis. An analysis of the hypothesis and the trials, however, points out major misconceptions about the hypothesis and unjustified outcome expectations. Wrong selection of patient population, endpoints that are incompatible with the hypothesis, poor choice of antioxidants, and lack of inclusion of biochemical markers of oxidative stress and markers of vascular response are some of the contributors to the "failure" of these trials.
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