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Related Experiment Videos

Paroxysmal attacks in multiple sclerosis.

P O Ostermann, C E Westerberg

    Brain : a Journal of Neurology
    |June 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Paroxysmal symptoms, including rare types like itching and diplopia, occurred in 22 of 235 multiple sclerosis (MS) patients. These attacks may stem from ephaptic activation within demyelinated lesions in the central nervous system.

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    Area of Science:

    • Neurology
    • Neuroscience

    Background:

    • Multiple sclerosis (MS) is a chronic neurological disease.
    • Paroxysmal symptoms are sudden, brief neurological events that can occur in MS patients.

    Purpose of the Study:

    • To investigate the occurrence and types of paroxysmal symptoms in patients with suspected or confirmed multiple sclerosis.
    • To propose a mechanism for the generation of these paroxysmal phenomena.

    Main Methods:

    • Retrospective analysis of 235 patients treated at a neurological clinic between 1966 and 1973.
    • Clinical observation and documentation of paroxysmal symptoms.

    Main Results:

    • Twenty-two out of 235 patients (9.4%) experienced paroxysmal symptoms.
    • The most common symptoms were paroxysmal dysarthria and ataxia (7 cases) and tonic seizures (5 cases).

    Related Experiment Videos

  • Novel paroxysmal symptoms, including paroxysmal hemiataxia, crossed paresthesiae, itching, and isolated diplopia, were observed.

    • Conclusions:

    • Paroxysmal symptoms are a notable feature in a subset of multiple sclerosis patients.
    • A hypothesis suggests these phenomena result from ephaptic activation of axons within demyelinated lesions in the central nervous system.