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SWISS-PROT: connecting biomolecular knowledge via a protein database.

E Gasteiger1, E Jung, A Bairoch

  • 1SWISS-PROT group, Swiss Institute of Bioinformatics, CMU, Genève. Elisabeth.Gasteiger@isb-sib.ch

Current Issues in Molecular Biology
|August 8, 2001
PubMed
Summary

Biological data growth necessitates advanced storage solutions. This review highlights efforts to integrate biomolecular databases, like SWISS-PROT, for better biological complexity understanding.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics
  • Proteomics

Background:

  • The rapid expansion of biological data has outpaced traditional publication methods, making databases crucial for research.
  • Biological databases are essential tools for scientists, storing diverse information like nucleic acid sequences, protein sequences, and tertiary structures.
  • Integrating these specialized databases is vital due to the interconnected nature of biological information.

Purpose of the Study:

  • To review the challenges and strategies for managing the explosive growth of biological data.
  • To emphasize the importance of integrating diverse biomolecular databases for a comprehensive understanding of biological complexity.
  • To showcase efforts in connecting biological information, using the SWISS-PROT protein database as a case study.

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Main Methods:

  • Classification of biological databases based on the type of information stored (sequence-related and specialized collections).
  • Analysis of the interconnectedness of different biomolecular databases.
  • Demonstration of data integration strategies through the SWISS-PROT database.

Main Results:

  • Biological databases have become indispensable resources for biological sciences over the past two decades.
  • Effective integration of sequence-related databases (nucleic acid, protein, structure) and specialized collections is achievable.
  • The SWISS-PROT database serves as an example of successful integration of biological information.

Conclusions:

  • The integration of biomolecular databases is essential for researchers to navigate and understand complex biological systems.
  • Continued development of data storage and integration methods is critical to keep pace with biological data generation.
  • Efforts like those in SWISS-PROT demonstrate the feasibility and benefits of connecting disparate biological information sources.