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Animal models used in identifying gender-related differences.
1Laboratory Animal Resources, Charles River Laboratories Discovery and Development Services, Worcester, Massachusetts 01608, USA. Bishop.curry@primedica.com
International Journal of Toxicology
|August 8, 2001
Summary
Identifying suitable animal models for screening gender-based differences is crucial. Many models, including primates and rodents, show conserved biological systems, allowing findings to correlate with human experiences.
Area of Science:
- Comparative biology
- Translational research
Background:
- Scientific community consensus on the need for gender-based difference screening models.
- Increasing demand for animal models that predict human outcomes.
Purpose of the Study:
- To review and identify appropriate animal models for studying gender-based differences.
- To assess the predictive value of these models for human health.
Main Methods:
- Literature review of various animal models.
- Analysis of species including nonhuman primates, rodents, rabbits, swine, quail, and fish.
Main Results:
- Multiple animal models are suitable for gender-based difference research.
- Conserved biological systems across species suggest potential correlation with human data.
Conclusions:
- Animal models offer valuable insights into gender-based biological variations.
- The selection of appropriate models is key for enhancing the translatability of research findings to humans.