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Updated: Aug 7, 2026

An Ex vivo Culture System to Study Thyroid Development
Published on: June 6, 2014
The effect of thyroxine administration on intestinal calcium absorption and calcium binding protein activity in the
Abstract:
Thyroxine (T4) injected subcutaneously into 3-week-old chicks (30 mug/kg body weight daily for 8 days) reduced the absorption of calcium from in vivo ligated loops of duodenum and the duodenal calcium binding protein (CaBP) activity measured by the Chelex ion exchange method. Chicks fed either a commercial diet or an artificial diet containing 0.5% or 1.0% calcium showed similar response to treatment with T4. A significant effect of T4 on either calcium absorption of CaBP activity could not be demonstrated in chicks fed a high calcium diet (2.0%). The possible mechanisms of action of T4 on calcium absorption are discussed.
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