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Updated: Aug 15, 2026

Vagus Nerve Stimulation as a Tool to Induce Plasticity in Pathways Relevant for Extinction Learning
Published on: August 21, 2015
Vagus nerve stimulation for the treatment of bilateral independent temporal lobe epilepsy
T M Alsaadi1, K D Laxer, N M Barbaro
1Department of Neurology, University of California, San Francisco, California, USA. taoufik.alsaadi@ucdmc.ucdavis.edu
Purpose:
We studied the effect of vagus nerve stimulation (VNS) on seizure reduction in patients with intractable epilepsy with bilateral independent temporal lobe foci.
Methods:
Ten patients who met the criterion of the presence of two distinctive clinical and ictal EEG seizure patterns were identified and followed up for 1 year.
Results:
Six patients had >50% reduction in their seizure frequency that persisted up to > or =1 year of follow-up, whereas four patients reported small or no reduction in their partial seizures.
Conclusions:
VNS is often effective and well tolerated in this select group of intractable epilepsy patients.

