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Related Experiment Videos

The dysmetabolic syndrome.

L Groop1, M Orho-Melander

  • 1Department of Endocrinology, Wallenberg Laboratory, Lund University, Malmö, Sweden. leif.groop@endo.mas.lu.se

Journal of Internal Medicine
|August 8, 2001
PubMed
Summary
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Metabolic syndrome, a cluster of conditions including hypertension and dyslipidemia, significantly increases cardiovascular mortality. Genetic and environmental factors likely contribute to its development, with ongoing research to identify new genetic links.

Area of Science:

  • Metabolic disorders
  • Genetics
  • Cardiovascular health

Background:

  • The World Health Organization (WHO) proposed the first unifying definition for metabolic syndrome in 1998.
  • Metabolic syndrome is diagnosed in patients with type 2 diabetes mellitus or impaired glucose tolerance who meet specific criteria.
  • Individuals with normal glucose tolerance (NGT) are considered to have the syndrome if they also exhibit insulin resistance.

Purpose of the Study:

  • To summarize the definition and prevalence of metabolic syndrome.
  • To highlight the association between metabolic syndrome and reduced survival, particularly cardiovascular mortality.
  • To explore the genetic and environmental underpinnings of metabolic syndrome.

Main Methods:

  • Review of the 1998 WHO definition of metabolic syndrome.

Related Experiment Videos

  • Analysis of prevalence data for impaired glucose tolerance (IGT) and type 2 diabetes.
  • Discussion of the interplay between genetic factors and environmental influences.

    • Main Results:

    • Approximately 40% of individuals with IGT and 70% of type 2 diabetes patients exhibit features of metabolic syndrome.
    • The presence of metabolic syndrome is linked to decreased survival rates, primarily due to increased cardiovascular mortality.
    • Common gene variants involved in lipolysis, thermogenesis, and glucose uptake are implicated as 'thrifty genes'.

    Conclusions:

    • Metabolic syndrome is a significant health concern associated with increased cardiovascular risk and reduced survival.
    • The syndrome likely arises from a combination of genetic predisposition and lifestyle factors.
    • Further research using random gene approaches may uncover additional genes contributing to metabolic syndrome.