Related Experiment Video

Updated: Aug 8, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Gene therapy for prostate cancer

J R Gingrich1, R D Chauhan, M S Steiner

  • 1Department of Urology, University of Tennessee Medical Center, 956 Court Avenue, H216, Memphis, TN 38163, USA. Jgingrich@utmem.edu

Current Oncology Reports
|August 8, 2001
PubMed

Insights

Gene therapy offers a novel approach to combat prostate cancer by targeting gene expression. While initial clinical trials show safety, further research is needed to confirm its long-term effectiveness in treating this malignancy.

Area of Science:

  • Molecular biology
  • Genetics
  • Oncology

Background:

  • Basic research is elucidating the molecular mechanisms underlying normal and abnormal cellular processes.
  • Gene therapy has emerged as a strategy to modulate gene expression involved in cancer development.
  • Prostate cancer involves malignant transformation of prostatic epithelial cells, a target for gene therapy.

Purpose of the Study:

  • To review recent preclinical research in gene therapy for prostate cancer.
  • To discuss current therapeutic strategies utilizing gene therapy.
  • To present recent findings from gene therapy clinical trials for prostate cancer.

Main Methods:

  • Review of preclinical studies on gene therapy for prostate cancer.
  • Analysis of current gene therapy approaches for prostate cancer treatment.
  • Compilation and summary of results from clinical trials of gene therapy in prostate cancer patients.

Main Results:

  • Gene therapy has demonstrated relative safety in initial clinical trials for prostate cancer.
  • Definitive evidence of durable therapeutic efficacy for gene therapy in prostate cancer is still pending.
  • Ongoing research continues to explore the potential of gene therapy in managing prostate cancer.

Conclusions:

  • Gene therapy is a promising, albeit developing, field for prostate cancer treatment.
  • Further clinical investigation is essential to establish the efficacy and long-term benefits of gene therapy.
  • The review highlights the progress and future directions of gene therapy in oncology.

More Related Videos

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration06:21

Virus Delivery of CRISPR Guides to the Murine Prostate for Gene Alteration

Published on: April 27, 2018

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance05:19

A New Technique for Treating Low-risk Prostate Cancer—Super Active Surveillance

Published on: November 7, 2025

Related Concept Videos

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...